CONTAINMENT TECHNOLOGY BY THE USE OF BARRIER ISOLATORS.

The Concept of Roll Compactor with Isolators was originally derived by the “Nuclear Industry” in order to keep the operators safe from radioactive Isotopes. Eventually this technology was adopted into the pharmaceutical industry to address operator safety from highly potent API’s. After years of evolution & upgrades the Barrier Isolators are looked upon as safer, easier & cheaper alternatives for handling High Potent API’s (Hormones, Cytotoxic, etc.).

Isolators provide a contained & controlled environment on a smaller scale compared to a clean room. The result is achieving ergonomic operation in an almost germ / contaminants free working atmosphere. All of this is achieved at a much smaller scale with minimized cost of cleaning, air cycles, validation & maintenance in comparison to a clean room.

At Chamunda Containment Solution’s we understand the need of the ever evolving API market to handle API drugs with maximum safety with comparative minimum cost of handling. We are deriving systems which are capable of handling wet, dry mass & Liquid from a range of OEL 3 to OEL 5. We are backed up by consultants from Europe who guides us in achieving the desired goal.

Chamunda has a complete setup for design & manufacturing of both Process equipment’s & Isolators in house. This provides us with absolute control over customization & equipment integration with Rigid Isolators*.

Our Product Range consists of the following.

•           Sampling & Dispensing Isolator.
•           Isolator for Granulation.
•           Isolator for Roll compactor & dry process line.
•           Isolator for Auto coater.
•           Close loop Granulation lines.
•           Colloid mill with containment.

Special Features

•           Integrated process equipment’s with Rigid –ve pressure Barrier Isolators
•           Options for material ingress i.e. Pass Box, RTP’s & SBV’s
•           Options for material discharge i.e. Out Pass Box, RTP’s, SBV’s, and Continuous Liners or BIBO Sleeves.
•           In Process Containers with SBV’s.
•           Pressure controlled cycles with Temperature, Humidity & O2 monitoring & control if required.
•           Integrated WIP systems with Skid.
•           Drum loading systems.
•           Safe Change filters.
•           Glove integrity testing.
•           Optimum ergonomics via ergo trials.
•      Complete automation using PLC + HMI (10”- Mitsubishi / optional Siemens make), compliant to 21 CFR if required.
•           Support for pressure test OEL test provided.
•           In compliance with cGMP norms.

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High Speed Double Rotary Tablet Press Machine

MACHINE APPLICATION

AMPLUS - III High Speed Double Rotary Tablet Press is aptly designed for use in pharmaceutical Industry for Large Batch size Production for Single Layer as well as Bi-Layer Tablets. It does find its applications in many other similar process industries.

MACHINE OPERATIONAL PRINCIPLE

The material (Blended Powder/ Granules) is to be filled to the die hole through the hopper and the Feeder. Then, the filling volume of the powder is adjusted by motorized Dozer & pressed under the Pre & Main Pressure Rolls. The tablets are formed under this process & discharged automatically through the discharge chute of the Tablet Press.

MACHINE DESCRIPTION

This is a Double Rotary Tablet Press with inbuilt 10 Ton Pre Compression & 10 Ton main Compression, with Key features of Interchangeable Turret facility among 51 STN D / 65 STN B/ 81 STN BB. This ergonomically designed machine is cGMP Compliant Tablet Press meeting all the parameters of Design (smooth corners & surfaces), Operator’s safety, Control systems, Metallurgy, Surface treatment and Easy accessibility for cleaning, assembling and dismantling of components etc.

AMPLUS - III series Rotary Tablet Presses are controlled by 15” IPC WITH COLOUR TOUCH SCREEN WITH 21 CFR PART 11 COMPLIANCE. IPC supports online helps to provide the Automation solutions through internet & hence minimize the Machine Down Time and production loss.

This series of machines are designed and made as per cGMP STANDARD & are capable to meet all international standards including USFDA & MHRA REQUIREMENTS.

A)    STRUCTURE

As the name suggests, the robust Structure design provides strength & stability to compression forces without vibration. Its sturdy construction based on 'TIE BEAM' design wherein the top frame, made of special C.I., supports the main body to withstand the pressure load during the entire tableting process. The trembling is also absorbed during the operation based on this structure. The structure is enclosed with SS 304 guards. The Tablet compression zone is covered with thick transparent acrylic guards. The machine is equipped with Anti Vibration mounts at the bottom.

B)    TURRET DRIVE

Centrally driven Turret is connected directly on the Main Drive Shaft of Heavy Duty Oil Immersed Gear Box to get the max torque at the Turret. It is designed to meet the standards of Low Noise Level below 80db. Large capacity motor ensures that there are no jerks or slippages while compressing even large tablets of size up to 25mm.

C)     TURRET

Highly accurately machined, 3 piece Turret with double tapper roller bearings, has SS 316 Die Table.

Upper & lower Punch Disk is made of Special Grade SGI Casting with Electroless Nickel Plating on the exposed portion in tableting zone. This Electroless Nickel plating provides excellent protection against corrosion from highly abrasive substances, salts, acids, alkali, humidity etc.

In upper Punch Disk, the keyway is given in upper punch bore for shaped punches. The Lower Disk is having the punch brake (Ball Plunger) which holds the lower punch, to reduce the weight variation & the Noise.

The lower wiper seal is fitted on the top part of the punch hole in order to block the Oil & dust from the Punch body.

Dies inserted in Die Holes are locked by specially designed & hardened Die Lock Assemblies.

The interchangeable Turret can be provided with option of ‘51D’, ‘65B’ or ‘81BB’ Tooling.

D)    PRE & MAIN COMPRESSION PRESSURE ROLLS ASSEMBLIES

Equal & High pressure of Pre & Main Compression rolls, improves the dwell time for better compression. It eliminates the problem of tablet capping and chipping even for difficult formulations or shaped tablets.

Pre & Main Compression Rolls are specially designed, to deliver uniform Pressure on both the Upper & Lower Punches.

The motorized Lower pressure Roll Assembly has Load Cell, fitted at Center the lower roll, which enables the compressing Force measurement & monitoring. (Numeric as well as Graphical)

E)     FILLING CAMS

3 types of the filling Cams are supplied along with the machine. A suitable one should be selected based on the Tablet Thickness. The maximum size of the Filling Cam is 20 mm.

 F)     FORCE FEEDER MECHANISM

Zero Clearance Force Feeder has User friendly design of the force feeder feeds the granules to the Die cavity uniformly. The Force Feeder has Single stage 3 Paddle design for optimum powder filling. Separate ACVFD Drive for Force Feeder is provided for uniform filling efficiency & weight control as well as to synchronize speed & feed both. Option of Clockwise & Anti Clockwise rotation of paddles can be selected from Touch Screen of IPC. It enables handling of difficult products with characteristics like low B.D., fluffiness, poor flow ability etc.

G)    FEATURES & ADVANTAGES OF AUTOMATION

•         All machine controls through IPC touch screen.

•         Auto sampling based on, either time or revolution or punch nos.

•         Initial startup & stop rejection by default

•         Auto rejection, of any single tablet, if out of prescribed compaction force limit based on CFC through AWC facility.

•         Graphical representation of pressure on individual punches at pre & main compression rolls.

•         4 level password securities to prevent unauthorized use.

•         Recipe management & recipe storage.

•         Audit trail reports with printing facility.

•         Post installation. PLC complaints can be handled by internet through team viewer

H)   AWC

•         The range of AWC is divided such as control, reject and data store.

•         Graphical representation of the value of both pre & main pressure.

•         Display of figurer and graph both for the value of pressure on each individual punch.

•         Indication / display, of any no. of the selected punch & the respective value of pressure applied on it.  

•         Filling depth can be adjusted, if the amount of filled powder is exceeded or shortened beyond preset value.

•         The faulty tablet will be rejected automatically through Single tablet rejection system.

•         All data like production, rejection samples taken. Batch time segments etc. are recorded.

•         Discharge chute with three compartments viz. Acceptable tablets, initial / auto reject & sampling tablets gate.

I)       CENTRALIZED SCADA MONITORING SYSTEM

Machine input & output status can be observed & monitored, in parallel to the machine connected panel, from outside, by any competent authorized person, while sitting in his office through any internet connected device.

BENEFITS OF SCADA:

•         Report generation in PDF.

•         Large no of recipe & data storage capability of IPC

•         Connectivity to any type of printer.

•         Graphical system representation.

•         Real time trending

•         Alarm history.

•         Audit trail.

•         Advanced security level.

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Tablet Compression Machines Market Size 2019-2026 | Product Capacity, Manufacturers, Share, Value, Consumption, Growth and Segmentation

The new research from Global QYResearch on TabletCompression Machines Market Report for 2019 expects to offer target gathering of people with the crisp point of view toward market and fill in the learning holes with the assistance of handled data and assessments from industry specialists. The data in the exploration report is all around handled and a report is aggregated by industry experts and prepared specialists in the field to guarantee of the nature of research.

The exploration is sponsored by broad and inside and out auxiliary research which includes reference to different measurable databases, national government archives, applicable patent and administrative databases, news articles, public statements, organization yearly reports, webcasts, budgetary reports, and various interior and outer restrictive databases. This evaluated information is cross-checked with industry specialists from different driving organizations in the market. After the whole confirmation process, these reports are imparted to topic specialists (SMEs) for adding further esteem and to pick up their keen feeling on the exploration. With such powerful procedure of information extraction, check, and finish, we solidly support the nature of our examination. With such broad and inside and out research and far reaching inclusion of data, it is dependably a plausibility of customers finding their ideal data in the report with walled in area of key segments and significant insights in all respects.

The worldwide Tablet Compression Machines advertise is esteemed at xx million US$ in 2018 is relied upon to achieve xx million US$ before the finish of 2025, developing at a CAGR of xx% amid 2019-2025.

This report centers around Tablet Compression Machines volume and incentive at worldwide dimension, territorial dimension and friends level. From a worldwide point of view, this report speaks to generally Tablet Compression Machines advertise measure by investigating authentic information and future prospect. Territorially, this report centers around a few key districts: North America, Europe, China and Japan.

At organization level, this report centers around the creation limit, ex-industrial facility value, income and piece of the pie for every maker canvassed in this report.

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CPEB4-FC – Front Control Double Rotary Tablet Press Machine

In the entry level segment of Double Rotary Tablet Press, CPEB4-FC is a proven model with the advantage of Front Control Operations.

Features:

• User Friendly Compact Design.
• Front Controls for Tablet Parameters.
• Compression Force up to 10 ton
• Main Motor with ACVFD and Electromagnetic Clutch.
• Force Feeder with AC Drive**
• Bi-Layer Attachment**

Technical Specifications:

MODEL	CPEB4-FC 27 ‘D’	CPEB4-FC 35 ‘B’	CPEB4-FC 45 ‘BB’
No of Stations	27	35	45
Tooling	D	B	BB
Max. Pressure (Ton)	10	6.5**	6.5**
Turret Speed (RPM)	17 to 42	17 to 42	17 to 42
Max Tablet Dia. (mm)	25	16	11
Max Output (Tablets/hr)*	136,080	176,400	226,800
Depth of Fill (mm)	20	17	17
Main Motor	5 HP, 1440 RPM	5 HP, 1440 RPM	5 HP, 1440 RPM
Upper Punch Penetration (mm)	3 to 6	3 to 6	3 to 6
Power Supply	415V, 3Phase, 50Hz	415V, 3Phase, 50Hz	415V, 3Phase, 50Hz

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Cantilever Type – Roll Compactor

FEATURES

• Cantilever Type Roll Design
• inline cake crusher & 2 stage granulator
• Roll – driven through ACVFD
• Hydraulic power pack for roll pressure & feed screw lifting
• Twin feed screw system for both horizontal & vertical feeding
• De-Aeration system in Vertical Feed Screw
• WIP provision only
• PLC System
• Mechanical Roll loading / unloading arrangement

OPTIONAL FEATURES

• Comprehensive Automation including
• Roll gap measurement & control
• 21 CFR Part 11 compliance
• Vacuum Powder Transfer System
• Closed loop system with structure & surrounding platform

MODEL	CPMRC – 300/125
Working Capacity – Throughput	100 to 400 kg / hr.
Roll Size (mm)	Ø300 X 125 W
Roll Speed	6 To 22 RPM (Variable through ACVFD)
Feed Screw Speed (Horizontal)	10 To 60 RPM (Variable through ACVFD)
Feed Screw Speed (Vertical)	10 To 200 RPM (Variable through ACVFD)
Roll Force	22 Ton by 2 Cylinder
Roll Drive Motor	12.5 HP
Feed Screw Motor (Horizontal)	2.0 HP
Feed Screw Motor (Vertical)	5.0 HP

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Élan – Double Rotary High Speed Tablet Making Machine

We have left a great impression in the pharmaceutical sectors situated in India as well as other nations for the utmost and impeccable quality of our tablet making machines. The reputation that we have earned is a result of our professional team who considers that the overall quality of the tablet is based on the efficiency and accuracy of the tablet making machines.

 

Our team concentrates on each aspect during the manufacturing of double rotary high speed tablet making machines

·         No compromise in Quality Standard

·         Use of High Graded Raw Material

·         Following Global Standards

·         Focused Examination throughout Manufacturing

·         Modern Technology Implementation

·         Numerous Post Manufacture Testing

·         Ensuring Defined Output

·         Ensuring Efficient Output

·         Cost Effectiveness

Our main focus is on Élan which is Double Rotary high speed (100 RPM) machine for higher table output with five ton pre - compression and ten ton main compression capable in ONE line ONE MILLION TABLETS PER HOUR. This output is greatest among India's largest manufactures and high end European tablet making machines. This Machine stands out due to its new aesthetic look and ergonomically compact design and is benefitted with higher table output. It combines in one machine the sophistication that today's tableting requirements together with well proven mechanical components and design. This tablet manufacturing machine fabricated from the perfect quality material, which makes this highly reliable and durable. It is fully capable of making different size and shape of tablets. This machine can be used in a 24/7 production environment. The implementation of the advanced technology and sophisticated engineering makes this machinery the perfect in the marketplace. Another major competitive advantage - this machine would be the first in the industry with semi automatic variant.

The Machine is the outcome of the proficiency of our experts who manufacture these with the help of the advanced technology in compliance to the international standards of quality. This Double Rotary High Speed Tablet Making Machines provides excellent throughput apt for various batch manufacturing. This machine is ideally designed by skilled professional along with the experienced engineers and technicians of our company. This machine has exceptional provisions such as Acrylic carbonate upper guards, Electromagnetic Clutch, & Lower Guards etc.

This machine is always chosen owing to their performance, quality in addition to competence. This offers problem free operations, robustly for comprehensive time period with no breaks. It is exceptionally strong as well as. It is unproblematic to maintain and keep clean, very enduring as well as truly faultless for tablet making operations.

This High Speed Double Rotary tableting making machine delivers the imperative aspects that defined a good quality of the tablet including size, profiling, shaping, texture, hardness, and tooling performance, anti-counterfeiting, stability, branding, taste and smell.

Therefore we can always tap all ongoing projects of A & B+ class customers who are eager to have such high outputs but overall, not willing to shell out exorbitant prices.  Truly, we intend to do our best shot to capitalize on this monumental opportunity and make this wonderful machine a great success. 

Features:

·         High Speed tablet making machine with outstanding performance, engineering,  and reliability.

·         Simple and convenient operation

·         Extremely robust quality engineering

·         Robust construction

·         Perfect dimensions

·         Front and easy controls

·         Excellent functionality and performance

·         Inter locked guards, for safety

·         Higher output suitable for large batch production

·         Multipunch tablet making

·         Electromagnetic Clutch

·         Low maintenance

·         Easy operation

·         Longer service life

·         Exceptional durability

·         Corrosion resistivity

·         Accessibility for ease of cleaning, maintenance and operation

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Duo Press – Bilayer Tablet Press

Backed by rich pharmaceutical industry experience, we are ready to offer high speed tablet making machines to our customers. This Chamunda DUO PRESS (Double Rotary Press) stands out due to its new aesthetic look and ergonomically compact design and is benefited with higher table output. It is developed to meet the R & D in the Tableting zone of the medical industry. This wonderful machine comes with the variant tooling like “B”, “D”, “D B” and “D B BB” to meet the specific and customize requirements. This machine is developed following with international standard bearing in mind requirements of customers. Our team focuses on the machinery part during the manufacturing of this machine. This machine is available at market competitive price.

High efficiency manufacture of pharmaceuticals requires the use of great quality tableting presses. Finished tablet is determined by the various operating parameters as well as the performance and design of tablet punches and dies.  Bilayer tablet is new concept of tablet for the successful creation of controlled release formulation with numerous features to provide a method of successful medicine delivery system. Bilayer tablet press is useful technology to conquer the shortcoming of the single layered pill. Bilayer pills can be a primary choice to avoid chemical incompatibilities. To reduce capital investment, tablet presses are used to produce such tablets. Using a DUO tablet press may be your perfect approach to producing a quality bi-layer tablets. Especially, when you wants high production output!

This machine is quality updated owing to their functionality, quality, in addition to competence. This provides easy & user-friendly operations, robustly for comprehensive time period with no breaks. It has exceptional supplies such as Electromagnetic Clutch, Adjustable Safety Upper Guard & contacts parts, Adjustable Upper punch penetration, made of SS 316. It is unproblematic to maintain and keep clean, very enduring as well as truly faultless for tablet making operations.

It is reliable and easy to operate with central driven, lubrication for centralized lubrication, and accessible front controls, suitable for large batch production.

Ideal Characteristics of Duo Press:

·         Central Drive System

o   No torque losses

·         Pre Compression Force 5+ tons

o   Better deaeration of material

o   Perfect Suits for dry granulation

·         Compatible for Bilayer Tablets

o   Allows Combination of 2 different APIs (Active Pharmaceutical Ingredients)

o   For an additional sales preposition

Features at a Glance:

·         Drive Arrangement   

o   Through variable frequency AC Drive, offering a complete solution to your AC Motor Speed.

·         All contacts parts made of SS 316

o   Contact parts including rotating Feeder  Paddles fitted with variable frequency drive, Discharge chute, Hopper, Hopper connector and butterfly valve for flow control

·         Three piece turret

o   with lower punch wiper seal and SS 316 Die Plate

·         Adjustable Safety Upper Guard

o   Operational interlock and Fully adjustable

·         Dust Nozzle

o   with Clamp- used for dust suppression

·         Ejection system

o   For weight checking or inspection purpose.

·         Main motor with ACVFD

o   It is reliable and affordable, has flexibility of control, and provides vital electrical energy savings through highly reduced electric bills.

·         Adjustable Upper punch penetration

o   This feature is very useful when tablet making very Shallow tablets.  

·         No foundation require because of anti vibration mounting

·         Inching System

·         High Speed Turret with Electro less nickel plating

·         Tablet compression zone

·         Anti-Reverse Protection

Optional Features:

·         5.7" Color Touch Screen

·         Turret and Feeder Motor Controls

·         3 Level Password Protection

·         Drive motor Controls and Fault Indication

·         Machine Parameters

·         Recipe Management

·         Comprehensive Reports

·         Force Control Parameters

·         Average compaction force indication

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