Manufacture of the tableting blend

In the pill pressing method, the most guideline is to confirm that the acceptable quantity of active ingredient is in every pill. Hence, all the ingredients ought to be well-mixed. If a sufficiently uniform mixture of the elements can't be obtained with straightforward mixing processes, the ingredients should be coarse before compression to assure an excellent distribution of the active compound within the final pill. 2 basic techniques square measure accustomed granulate powders for compression into a tablet press: wet granulation and dry granulation. Powders that may be mixed well don't need granulation and might be compressed into tablets through direct compression.

Wet granulation

Wet granulation could be a method of employing a liquid binder to gently agglomerate the powder mixture. The number of liquid has got to be properly controlled, as over-wetting can cause the granules to be too onerous and under-wetting can cause them to be too soft and friable. binary compound solutions have the advantage of being safer to touch upon than solvent-based systems however might not be appropriate for medicine that square measure degraded by chemical reaction.

Procedure

1.         The active ingredient and excipients square measure weighed and mixed.

2.         The wet granulate is ready by adding the liquid binder–adhesive to the powder mix and admixture completely. Samples of binders/adhesives embody binary compound preparations of starch, natural gums like tree, and polyose derivatives like methyl group polyose, gelatin, and providence.

3.         Screening the damp mass through a mesh to create pellets or granules.

4.         Drying the granulation. a traditional tray-dryer or fluid-bed appliance square measure most typically used.

5.         When the granules square measure dried, they're had a screen of smaller size than the one used for the wet mass to form granules of uniform size.

Low shear wet granulation processes use terribly straightforward admixture instrumentality, and might take a substantial time to attain a uniformly mixed state. High shear wet granulation processes use instrumentality that mixes the powder and liquid at a awfully quick rate, and therefore hurries up the producing method. Fluid bed granulation could be a multiple-step wet granulation method performed within the same vessel to pre-heat, granulate, and dry the powders. It’s used as a result of it permits shut management of the granulation method.

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Sieving & Grading Machine GMP Model (Vibro Sifter)

Vibro Sifter offered is provided with multi-deck and dust-proof cover support and provides working on vibratory, rotary and magnetic principles that makes these suitable for sieving and screening of chemicals, cosmetics and pharmaceuticals. Finding use in sieving and screening of pharmaceuticals, chemicals, cosmetics, these are offered in different working capacities and are used for separation of mass composition of solid and liquid. These also come with circular gyratory screens that provide for efficient separation of mass composition of liquid from solid, solids from solids.

Features:

•    Simple & Compact construction.
•    Faster Separation
•    Double & Triple deck screens with outlet and hopper for bottom deck
•    available on request.
•    Lesser Maintenance and Power Consumption than the Conventional Sifter.
•    Easy dismantling and cleaning facility

Models	CPMVS 20”	CPMVS 30”
Screen Diameter	510 mm	750 mm
Charging Height	1000 mm	1150 mm
Discharging Height	600 mm	750 mm
Motor	0.5 HP, 3 Ø, A.C.	1 HP, 3 Ø, A.C.

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Colloid Mill- State of Art perfect homogenizer | emulsifier | Dispersing | Milling from CHAMUNDA

In-depth Knowledge of the domain-Pharma Machinery for Solid Oral Dosage, highly creative professionals and capability to convert imagination in to reality makes CHAMUNDA PHARMA MACHINERY PVT.LTD (CPMPL) as a preferred supplier for Pharma Machinery.

From its inception (1981) with the help of experienced engineers, we are able to offer a wide range of Colloid Mill. The company’s expertise in delivering unmatched products has helped in to earn the reputation of a veteran within the introduction of Colloid Mill during the early stage of companies expansion in early 80’s.

Super fine grind, Homogenize, Disperse, Mix and emulsify in single process TechniK-is one word to define our Colloid Mill.

Principle: A colloid mill does its work by hydraulic shear, bringing to bear a tremendous amount of energy on a small portion of material in the form of a thin film. This will reduce particles to their ultimate crystal size by breaking up the agglomerates into which they form. In the case of emulsions, the same principle holds. As the particles of the dispersed phase of the emulsion get smaller, it requires progressively more energy to overcome the surface tension holding them together. Enormous hydraulic shear is needed to do the job and a colloid mill is the ideal device to apply this force. Please refer attached white paper on Colliod Mill for your kind ref.

CPMPL engineers and application experts are available to assist you with selection of machine type as well as provide you with advice regarding installation of the machine into existing or new process systems. What else do you need? Please write to us in case you need us to attend your specific request if any.

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Do your pharmaceutical Tablet Productions require speed and precision.-We have solution for it.

Do your pharmaceutical Tablet Productions require speed and precision? CLIT PRESS II-Tablet press Machine is the answer.

Cutting edge technology, great reliability and unique design with easy to use and to maintain, these are the main features of our CLIT PRESS II. It’s really allows to Do your pharmaceutical Tablet Productions require speed and precision.-We have solution for it.-these are the words from the actual user/Machine Operator.

CLIT PRESS II machine is distinguished by the high technology, quality and reliability. These traits are guaranteed by an integrated and continuously upgraded production system. It’s is a modular design able to support various dosing units of powder. The high sophisticated manufacturing technology used for the moving parts ensures the precision of all the machine functions.

The design of CLIT PRESS II means precise functioning and high performances, characteristics which make this Tablet Press machine ideal for production of small, medium and large lots.The many options installed as standard enable CLIT PRESS II to satisfy all the production demands of the pharmaceutical companies.

Clit Press II offers a noticeable modularity:

• The standalone control cabinet contains all electrical and electronic             components

• 29 Stations Press is specially designed to compress DS, Capsules &                   Oval shaped tablets 23mm & 19mmg respectively

• The turret has a wider pitch circle diameter

• Geometry of the compression rolls for extended Dwell time even at a             High Speed

• Tablet press equipped with Three Piece Turret with SS 316 Die Plate with         Lower Punch Wiper Seal (Wiper seal only in D & B Tooling)

Let’s get to know it better by referring attached details of our CLIT PRESS II- Award Winning Tablet Press Machine.Our Record says this machine is installed at more than 1000 places & this is the highest in number any company has installed for the rated capacity.

Feel free to contact undersigned in case you have any query.

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Multi-Purpose Equipment-Redefine the excellence in R&D by Chamunda-India

In Innovation, there is no rule except redefining creative excellence by putting your imagination into the reality. Driven by this fact, we at CHAMUNDA have crafted Multi-Purpose R&D equipment to cater the need of R&D Department. These equipment is originally designed a long back but haven’t got an opportunity to present it in a full range. Multi-Purpose Equipment is based on a powerful drive unit available in two versions. The various attachments can be easily and quickly connected by means of a flange coupling.

The Multi-Purpose Equipment is ideal for small scale production in the pharmaceutical, chemical, cosmetic and food industries. It fits perfectly into Research & Development of tablets, ointments, creams and more. The modular design is compact, economical and offers a powerful motor drive with a wide range of easily interchangeable attachments for various purposes.

Main benefits of the modular Multi-Purpose R&D Equipment is:

•   Little lab space needed
•   Constant product quality - improved production
•   Economical capital cost - one drive, many attachments
•   High quality

For your quick reference we have attached herewith the details of Multi-Purpose R&D Equipment. Hope it’s interesting reading.

With these significant strategic moves today, techno managerial excellence and a blueprint of tomorrow in our mind, we at Chamunda Pharma Machineries believe that tomorrow is truly ours! Isn’t it!

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Tablet Press- Double Sided Square Rotary Tablet Press – GMP Model

APPLICATION & PROCESS: 

Double Sided Tablet Press Machine is used for production of simple and precise tablets from powder in Pharmaceutical and relevant Industries.

KEY FEATURES AT GLANCE

THE MACHINE CONCEPT

The basic construction of the machine consists of:

• Rigid base frame fitted on rigid body
• Tablet Compression Zone
• Electric Control Panel

THE ERGONOMICS DESIGN

The CPEB4 has been completely new designed according to the most modern ergonomic aspects.

•          GMP Model

•          Easy cleaning and Changeover

•          Stainless steel and acrylic surrounding

•          Easy to operate and maintenance

THE DRIVE

The machine is equipped with VARIABLE SPEED PULLEY. The turret is driven by PB worm/Equivalent Material fitted to a bearing mounted worm shaft gear box which is driven by motor. Small adjustment between the worm and worm wheel to allow for any wear which can be adjusted in turn extending it’s life.

THE GRAVITY FEED FRAME

Non mechanical open gravity feed frame are standard equipment in this machine. The gravity feed frame fitted with easy removed Fixing knob on rigid base plate and can be easily set and maintained at the desired height. Resetting of the feed frame base is not required during change over and cleaning. The gravity feed frame fitted with re-circulating band to keep avoid spilling of the powder.

THE POWDER LEVEL 

Powder level in the feed frame can be easily adjusted by hopper support bracket and knob. These adjustment are possible without having to shut down the machine and open the guard

THE TURRET AND DIE TABLE

We are proposing SS 316 die plate three piece turret along with SS 316 Powder Contact Parts. 

 

THE CAMS DESIGN

For smooth operation, all CAMS are calculated by computer with a harmonic profile to fluent operation and minimum wear.

THE UPPER PUNCH PENETRATION 

Adjustable upper punch penetration is provided as a standard features of CPEB4 model. The system provides the following features.

• Change of level of compression of the tablet is possible in the die
• Reduce ejection loads of difficult product like floppy or sticky
• Die life can be increased by changing the level of tablet compression and reversing the dies

THE OVERLOAD AND PRESSURE RELEASE MECHANISM

·  The compression spring overload pressure release mechanism fitted to lower pressure roll for applying unique systems fitted to lower pressure roll for applying unique compression force. It combines the advantage of selecting constant force or constant thickness of the tablet press. The overload pressure release ensures any overloading transmitted to the punches without major damage. The overload pressure release should always be set to relieve the pressure with minimum effort consistent with the diameter and hardness of the tablet being made.

THE DUST EXTRACTION ARRANGEMENT

·  At high speed, the Dust Extraction system is prerequisite. The effective dust suction nozzles are fitted at compression zone with quick release design for easy cleaning.

THE LUBRICATION SYSTEMS

·  The CPEB4 model is equipped with one shot lubrication systems to serve lubrication to all pressure roll pin. Oil cups are provided wherever continuous lubrication is required.

THE NOISE LEVEL

·  The compression are is completely encapsulated and the machine itself is surrounded by sound absorbing covering. Therefore, the noise level is below 85 dB even under higher load. The machine is mounted on anti-vibration mounts.

THE CONTROL PANEL

The control panel fitted on front side of the machine. The control panel allows easy and safe adjustment of operating, easy cleaning and gives excess space for setting, change over and cleaning of the machine. The control panel is fitted with digital tablet counter, RPM Meter and Push Buttons. The electric components closed panel installed in the machine cabinet fitted with MCB, Overload relay, Contractors etc.

THE CLEANLINESS AND CLEANABILITY

The tableting zone has no painted surface and corner to avoid dust traps. The large cabinet combined with acrylic guards gives excellent access area for cleaning. Dust extractor nozzle significantly reduces the dust levels in the tableting zone.

THE ELECTRIC AND ELECTRONICS

• Clearly defined wiring
• High End Products used for longer life & improved Reliability of the machine Enhancing value of product
  
  
  TECHNICAL SPECIFICATION
  
  

  Sr.No.	MODEL	CPEB4 – 27 ‘D’ TOOLING	CPEB4 – 35 ‘B’ TOOLING	CPEB4 – 45 ‘BB’ TOOLING
  1.	No. Of Station	27	35	45
  2.	Tooling	D	B	B
  3.	Max. Operating Load (Tons)	10 Tons	6.5 Tons	6.5 Tons
  4.	Max. Tablets Dia. (mm)	Ø 25 mm	Ø 16 mm	Ø 11 mm
  5.	Max. Depth Of Fill (mm)	20	17.5	17.5
  6.	Upper Punch Penetration (mm)	1.5 to 8 mm	1.5 to 8 mm	1.5 to 8 mm

• The output will depend on the physical and chemical properties of material being processed. In case of Tableting machine, it depends on tablet shape, weight, thickness & ambient conditions.

• Electric voltage and frequency can be provided as per customer’s requirement.

• The right for modification in the design and the specs are reserved without prior notice.

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